Gene - Simply, gene expression is the flow of genetic information from gene to protein. Gene expression is a vital process in cells that ensures specific proteins are created at the right time and in the right quantities. Gene Expression. When a cell requires a specific protein, it activates the corresponding gene. This activation initiates a series ...

 
Find The Diet That Works For You. Find The Diet That Works For. You. Since 2018, Gene Food has been a reliable resource for personalized nutrition insights rooted in science. Our software analyzes genetic data and uses polygenic risk scoring to cut through the noise and find the diet that works for you.. Atandt coverage maps

Horizontal gene transfer (HGT) is arguably the most conspicuous feature of bacterial evolution. Evidence for HGT is found in most bacterial genomes. Although HGT can considerably alter bacterial ...Jan 3, 2024 · AR (Androgen Receptor) is a Protein Coding gene. Diseases associated with AR include Androgen Insensitivity, Partial and Spinal And Bulbar Muscular Atrophy, X-Linked 1.Among its related pathways are Gene expression (Transcription) and Signaling by Rho GTPases.Gene Ontology (GO) annotations related to this gene include DNA-binding …The past few months have brought electrifying news that, for the first time, a gene therapy has provided some hearing to children born with mutations that left them …Gene Autry (born September 29, 1907, near Tioga, Texas, U.S.—died October 2, 1998, Los Angeles, California) American actor, singer, and entrepreneur who was one of Hollywood’s premier singing cowboys and the best-selling country and western recording artist of the 1930s and early ’40s.. Autry, who grew up in Texas and Oklahoma, had aspired to be a …GEO DataSets. This database stores curated gene expression DataSets, as well as original Series and Platform records in the Gene Expression Omnibus (GEO) repository. Enter search terms to locate experiments of interest. DataSet records contain additional resources including cluster tools and differential expression queries. The Gene Keys book shares a new understanding of core beliefs explained with the inner language of the spectrum of consciousness. Each Gene Key contains a shadow, a gift, and a siddhi. Within each shadow is a unique repressive and reactive nature. These two poles together play out the human drama.DICER1 (Dicer 1, Ribonuclease III) is a Protein Coding gene. Diseases associated with DICER1 include Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor and Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors.Among its related pathways are Gene Silencing by RNA and Overlap between signal …Mar 26, 2021 · It is so important that it is sometimes called the “central dogma.”. Through the processes of transcription and translation, information from genes is used to make proteins. Genes make proteins through two steps: transcription and translation. This process is known as gene expression. Learn more about how this process works. Basically, a gene is used to build a protein in a two-step process: Step 1: transcription! Here, the DNA sequence of a gene is "rewritten" in the form of RNA. In eukaryotes like you and me, the RNA is processed (and often has a few bits snipped out of it) to make the final product, called a messenger RNA or mRNA. a part of the DNA in a cell that controls the physical development, behaviour, etc. of an individual plant or animal and is passed on from its parents: The illness is believed to be …An experimental gene therapy tested in young children with an inherited form of deafness restored some hearing for most of them. For the first time, gene therapy is …Support Stated Clearly on Patreon: https://www.patreon.com/statedclearlyYou've probably heard about GMOs or Genetically Modified Organisms but what exactly i...A novel gene therapy approach has given five children who were born deaf the ability to hear. The method, which overcomes a roadblock presented by large genes, may be useful in other treatments, according to researchers. The work, conducted in Fudan, China, by a team co-led by Zheng-Yi Chen at the Massachusetts Eye and Ear Infirmary and …19 hours ago · A gene is a section of DNA which controls part of a cell's chemistry - particularly protein production. is a small section of DNA on a chromosome, which codes for a particular sequence of amino ...Gene expression and regulation describes the process by which information encoded in an organism's DNA directs the synthesis of end products, RNA or protein. The articles in this Subject space ... GeneReviews Glossary - GeneReviews® - NCBI Bookshelf is a comprehensive guide to the terms and concepts used in GeneReviews, a collection of expert-authored, peer-reviewed chapters on specific genetic disorders. The glossary explains the meaning and usage of clinical, molecular, and genetic terms, as well as abbreviations and acronyms. It …Gene therapy is at an inflection point. Recent successes in genetic medicine have paved the path for a broader second wave of therapies and laid the foundation for next-generation technologies.Jan 19, 2024 · Celle-ci contient les noms, prénoms, date et lieu de naissance, filiation de chaque soldat ainsi que des indications sur son parcours militaire. Généalogie : retrouvez vos ancêtres en ligne, créez gratuitement votre arbre généalogique, découvrez et partagez l'histoire de votre famille sur Geneanet. RefSeq gene is a subset of NCBI’s RefSeq database, and are defined based on review from curators of locus-specific databases and the genetic testing community. They form a stable foundation for reporting mutations, for establishing consistent intron and exon numbering conventions, and for defining the coordinates of other biologically ... 5 days ago · The gene therapy consists of a harmless virus carrying new otoferlin genes in two drops of liquid that are delicately injected down the length of the cochlea, delivering the genes to each hair cell. Gene Wilder (Jerome Silberman; June 11, 1933 – August 29, 2016) was an American actor, author, comedian, director and screenwriter. He was most famous for his acting work and in particular for the movies he made with Mel Brooks which include The Producers, Blazing Saddles and Young Frankenstein.He also played the part of Willy Wonka in the musical …Gene knockout by mutation is commonly carried out in bacteria. An early instance of the use of this technique in Escherichia coli was published in 1989 by Hamilton, et al. In this experiment, two sequential recombinations were used to delete the gene. This work established the feasibility of removing or replacing a functional gene in bacteria.Gene Autry (born September 29, 1907, near Tioga, Texas, U.S.—died October 2, 1998, Los Angeles, California) American actor, singer, and entrepreneur who was one of Hollywood’s premier singing cowboys and the best-selling country and western recording artist of the 1930s and early ’40s.. Autry, who grew up in Texas and Oklahoma, had aspired to be a …May 17, 2016 · 是我今年读过最棒的书了。如果2023年的书里面要推荐一本,那一定是<The Gene>。 作为一个天天接触gene相关技术和发展的人,还是第一次这么系统得了解整个history。作者用他的春秋笔法,把历史写成了一本小说。so impressed!RefSeq gene is a subset of NCBI’s RefSeq database, and are defined based on review from curators of locus-specific databases and the genetic testing community. They form a stable foundation for reporting mutations, for establishing consistent intron and exon numbering conventions, and for defining the coordinates of other biologically ... Jan 19, 2024 · 00:00. 00:39. Messenger RNA (abbreviated mRNA) is a type of single-stranded RNA involved in protein synthesis. mRNA is made from a DNA template during the process of transcription. The role of mRNA is to carry protein information from the DNA in a cell’s nucleus to the cell’s cytoplasm (watery interior), where the protein-making machinery ... The lac operon of E. coli contains genes involved in lactose metabolism. It's expressed only when lactose is present and glucose is absent. Two regulators turn the operon "on" and "off" in response to lactose and glucose levels: the lac repressor and catabolite activator protein (CAP). The lac repressor acts as a lactose sensor. This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a …A gene is the basic physical and functional unit of heredity, composed of a segment of DNA that codes for a trait. Learn the origin, structure, function and examples of genes …Gene. Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide. The gene therapy, which used a recombinant adeno-associated virus serotype 2 (rAAV2) vector to deliver a functional ASPA gene, was safe and associated with modest phenotypic improvement and a ...Global gene expression profiling has been widely used to detect target genes associated with a special action or status of life such as a stage of plant development or host plant defense. In this study, the experiments were designed to identify R genes with altered expression in sorghum plants in response to attack by aphids. As shown in ...The ‘balding gene’ explained. When hair loss is caused by your genetics, it occurs in a predictable pattern often referred to as male pattern baldness (MPB) or female pattern baldness (FPB ...4 days ago · The Human Gene Database. GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes. The knowledgebase automatically integrates gene-centric data from ~150 web sources, including genomic, transcriptomic, proteomic, genetic, clinical and …TNF (Tumor Necrosis Factor) is a Protein Coding gene. Diseases associated with TNF include Malaria and Asthma . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TNFR1 Pathway . Gene Ontology (GO) annotations related to this gene include identical protein binding and cytokine activity .Regulation of Gene Expression. Figure 17.1 The genetic content of each somatic cell in an organism is the same, but not all genes are expressed in every cell. The control of which genes are expressed dictates whether a cell is (a) an eye cell or (b) a liver cell. It is the differential gene expression patterns that arise in different cells that ...Gene. Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide. DICER1 (Dicer 1, Ribonuclease III) is a Protein Coding gene. Diseases associated with DICER1 include Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor and Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors.Among its related pathways are Gene Silencing by RNA and Overlap between signal …A genetic disorder is a detrimental trait caused by an abnormal gene. The abnormal gene may be inherited or may arise spontaneously as a result of a new mutation. Gene abnormalities are fairly common. Every human carries an average of 100 to 400 abnormal genes (different ones in different people). The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia.Nov 7, 2017 · Gene Expression Introduction Gene expression. the phenotypic manifestation of a gene or genes by the processes of genetic transcription and genetic translation. Gene expression analysis. the determination of the pattern of genes expressed at the level of genetic transcription, under specific circumstances or in a specific cell. How It Works A gene is the basic physical and functional unit of heredity. Genes are made up of DNA and each chromosome contains many genes. Learn how to identify, name, and classify genes, and how …The ‘balding gene’ explained. When hair loss is caused by your genetics, it occurs in a predictable pattern often referred to as male pattern baldness (MPB) or female pattern baldness (FPB ...Jan 11, 2024 · Gene therapy is a medical technique that uses sections of DNA to treat or prevent a disease or medical disorder. Genes are inserted into a patient’s cells and tissues to treat a disease.The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia.The timing of gene silencing during mouse iXCI and the subsequent gene reactivation has been followed by nascent-RNA FISH and allele-specific, single-cell RNA sequencing 7,63,65, and the changes ...6 days ago · Gene expression is the process by which the information encoded in a gene is turned into a function. This mostly occurs via the transcription of RNA molecules that code for proteins or non-coding RNA molecules that serve other functions. Gene expression be thought of as an “on/off switch” to control when and where RNA molecules and proteins ... Gene. Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.The gene therapy, which used a recombinant adeno-associated virus serotype 2 (rAAV2) vector to deliver a functional ASPA gene, was safe and associated with modest phenotypic improvement and a ...A genetic disorder is a detrimental trait caused by an abnormal gene. The abnormal gene may be inherited or may arise spontaneously as a result of a new mutation. Gene abnormalities are fairly common. Every human carries an average of 100 to 400 abnormal genes (different ones in different people). Gene is a multidisciplinary journal that publishes papers on the regulation, expression, function, and evolution of genes in all biological contexts, including …The Selfish Gene is a 1976 book on evolution by ethologist Richard Dawkins, in which the author builds upon the principal theory of George C. Williams's Adaptation and Natural Selection (1966). Dawkins uses the term "selfish gene" as a way of expressing the gene-centred view of evolution (as opposed to the views focused on the organism and the …3 days ago · Gene therapy has allowed several children born with inherited deafness to hear. A small study published Wednesday documents significantly restored hearing in five of six kids treated in China. On ... 1920s–1973. Eugene Bertram Krupa (January 15, 1909 – October 16, 1973) [1] was an American jazz drummer, bandleader and composer. [2] [3] Krupa is widely regarded [citation needed] as one of the most influential drummers in the history of popular music. His drum solo on Benny Goodman 's 1937 recording of "Sing, Sing, Sing" elevated the role ... Gene expression and regulation describes the process by which information encoded in an organism's DNA directs the synthesis of end products, RNA or protein. The articles in this Subject space ... Jan 11, 2024 · Gene therapy is a medical technique that uses sections of DNA to treat or prevent a disease or medical disorder. Genes are inserted into a patient’s cells and tissues to treat a disease.Jan 3, 2024 · GATA1 (GATA Binding Protein 1) is a Protein Coding gene. Diseases associated with GATA1 include Thrombocytopenia With Beta-Thalassemia, X-Linked and Thrombocytopenia, X-Linked, With Or Without Dyserythropoietic Anemia.Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative …The gene therapy, which used a recombinant adeno-associated virus serotype 2 (rAAV2) vector to deliver a functional ASPA gene, was safe and associated with modest phenotypic improvement and a ...Nov 21, 2023 · The gene expression definition is the process of using the information in a gene to create a protein inside a cell. All cells have gene expression as it is the process that creates protein. To ... Jan 3, 2024 · UniProtKB/Swiss-Prot Summary for CAMP Gene. Antimicrobial protein that is an integral component of the innate immune system (PubMed: 22879591, 16637646, 18818205, 9736536, 14978112 ). Binds to bacterial lipopolysaccharides (LPS) (PubMed: 16637646, 18818205 ). Acts via neutrophil N-formyl peptide receptors to enhance the …The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood. This condition is rare, and is known as Li …Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, …A world-first trial of a gene therapy to cure a form of deafness has begun, potentially heralding a revolution in the treatment of hearing loss. Up to 18 children from the UK, Spain and the US are ...THURSDAY, Jan. 25, 2024 (HealthDay News) -- Five of six Chinese children born deaf due to a rare genetic defect now have the ability to hear, thanks to an experimental gene …Breakthrough gene therapy could offer hope for treating hereditary hearing loss 01:39. Experimental gene therapy studied in both China and the United States has …Mar 27, 2018 · 内容简介 · · · · · ·. 《基因XII》是分子生物学领域一部具有鲜明特色的教材。. 数十年来,它为一直处于快速发展之中的分子生物学提供了现代的解读。. 新版的《基因12》继续展现了基因结构、测序、组构和表达等方面的新资讯和前沿成果。. 书中各部分内容 ...GeneCards Summary for PPARG Gene. PPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene. Diseases associated with PPARG include Lipodystrophy, Familial Partial, Type 3 and Body Mass Index Quantitative Trait Locus 11 . Among its related pathways are PIP3 activates AKT signaling and Gene …6 days ago · Gene expression is the process by which the information encoded in a gene is turned into a function. This mostly occurs via the transcription of RNA molecules that code for proteins or non-coding RNA molecules that serve other functions. Gene expression be thought of as an “on/off switch” to control when and where RNA molecules and proteins ... Jan 3, 2024 · IGF1 (Insulin Like Growth Factor 1) is a Protein Coding gene. Diseases associated with IGF1 include Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency and Insulin-Like Growth Factor I.Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.Gene Ontology (GO) annotations …The timing of gene silencing during mouse iXCI and the subsequent gene reactivation has been followed by nascent-RNA FISH and allele-specific, single-cell RNA sequencing 7,63,65, and the changes ...YAP1 (Yes1 Associated Transcriptional Regulator) is a Protein Coding gene. Diseases associated with YAP1 include Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Impaired Intellectual Development and Uveal Coloboma-Cleft Lip And Palate-Intellectual Disability.Among its related pathways are …Feb 8, 2019 · genetic Having to do with chromosomes, DNA and the genes contained within DNA. The field of science dealing with these biological instructions is known as genetics. People who work in this field are geneticists. genome The complete set of genes or genetic material in a cell or an organism. Expression Atlas is an open science resource that gives users a powerful way to find information about gene and protein expression. Our mission is to provide the scientific community with freely available information on the abundance and localisation of RNA (and proteins) across species and biological conditions such as different tissues, cell ... The origin of The Selfish Gene is intriguing. Dawkins revealed in the first volume of his memoirs, An Appetite for Wonder (Bantam, 2013; see E. Scott Nature 501, 163; 2013), that the idea of ...Jan 3, 2024 · This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine in the purine catabolic pathway. Various mutations have been described for this gene and have been linked to human …The Gene Keys book shares a new understanding of core beliefs explained with the inner language of the spectrum of consciousness. Each Gene Key contains a shadow, a gift, and a siddhi. Within each shadow is a unique repressive and reactive nature. These two poles together play out the human drama.Overview. The BRCA gene test looks for DNA changes that increase the risk of breast cancer and ovarian cancer. It uses a sample of blood or saliva to look for the changes. DNA is the genetic material inside cells. It holds the instructions, called genes, that tell cells what to do. Harmful changes in the genes can increase the risk of cancer.A gene is the basic physical and functional unit of heredity, composed of a segment of DNA that codes for a trait. Learn the origin, structure, function and examples of genes …Gene is a multidisciplinary journal that publishes papers on the regulation, expression, function, and evolution of genes in all biological contexts, including …Identification and comparison of cell type-associated expression across multiple data sets. The goal of this study is to define and explore cell type-specific gene expression patterns via a meta ...Jan 3, 2024 · YY1 (YY1 Transcription Factor) is a Protein Coding gene. Diseases associated with YY1 include Gabriele-De Vries Syndrome and Insulinoma . Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling . Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and ...Gene Structure Display Server. Gene Features. Input features in BED format : Input data: Example. or upload file: Other Features to Display. Output (Phylogenetic Tree/Order) Image Format.A gene is the basic physical and functional unit of heredity, composed of a segment of DNA that codes for a trait. Learn the origin, structure, function and examples of genes …

Gene therapy is a type of treatment being developed to fight diseases that are caused by genetic defects. This is a relatively new medical intervention that is mainly in the experimental phase, including human trials and animal trials, for the treatment of some conditions, such as cystic fibrosis. Gene therapy aims to change the unhealthy .... Bloghallucinate nyt crossword clue

gene

1 day ago · A gene therapy trial has successfully provided children who were born deaf the ability to hear. The trial, conducted in Fudan, China, at the Fudan University’s Eye & ENT Hospital and by a team ... INS (Insulin) is a Protein Coding gene. Diseases associated with INS include Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10.Among its related pathways are Insulin receptor signalling cascade and Transport to the Golgi and subsequent modification.Gene Ontology (GO) annotations related to this gene include …A genetic disorder is a detrimental trait caused by an abnormal gene. The abnormal gene may be inherited or may arise spontaneously as a result of a new mutation. Gene abnormalities are fairly common. Every human carries an average of 100 to 400 abnormal genes (different ones in different people). Gene therapy is a medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells.. The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of …Introduction to the Gene Expression Analysis. 2016:1434:29-43. doi: 10.1007/978-1-4939-3652-6_3. In 1941, Beadle and Tatum published experiments that would explain the basis of the central dogma of molecular biology, whereby the DNA through an intermediate molecule, called RNA, results proteins that perform the functions in cells. 3 days ago · Updated 3:31 PM PST, January 24, 2024. Gene therapy has allowed several children born with inherited deafness to hear. A small study published Wednesday documents significantly restored hearing in five of six kids treated in China. On Tuesday, the Children’s Hospital of Philadelphia announced similar improvements in an 11-year-old boy treated ... Global gene expression profiling has been widely used to detect target genes associated with a special action or status of life such as a stage of plant development or host plant defense. In this study, the experiments were designed to identify R genes with altered expression in sorghum plants in response to attack by aphids. As shown in ...Jan 3, 2024 · KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with KIT include Piebald Trait and Gastrointestinal Stromal Tumor . Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by juxtamembrane domain KIT mutants . Gene Ontology (GO) annotations …Aug 14, 2023 · Bookshelf ID: NBK532999 PMID: 30422591. Epigenetics is the study of heritable and stable changes in gene expression that occur through alterations in the chromosome rather than in the DNA sequence. [1] Despite not directly altering the DNA sequence, epigenetic mechanisms can regulate gene expression through chemical modifications of DNA bases ... Information from a gene is used to build a functional product in a process called gene expression. A gene that encodes a polypeptide is expressed in two steps. In this process, information flows from DNA →. ‍. RNA →. ‍. protein, a directional relationship known as the central dogma of molecular biology. Gene therapy, introduction of a normal gene into an individual’s genome in order to repair a mutation that causes a genetic disease. Human gene therapy has been attempted on somatic (body) cells for diseases such as cystic fibrosis and cancer. Learn about approaches to and issues surrounding gene therapy.Jan 3, 2024 · NCBI Gene Summary for ABL1 Gene. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this …Human Gene is a companion title to Gene and a member of the Gene Family. Human Gene publishes meta-analysis, genetics, genome projects, and regulation, expression, function, and evolution of genes that are relevant to human genetics.Examples include but are not limited to Meta-Analysis Papers - statistical reviews of the published literature of human …Gene is a dog breeder wandering in the Commonwealth in 2287. Gene wanders the Commonwealth to sell dogs he raised himself, albeit begrudgingly, stating that he "feels blue for a week after selling a dog." Gene is a character that the Sole Survivor may meet in the Commonwealth in Gene the Reluctant Dog Vendor random encounter. If the Sole …Jan 3, 2024 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit.Among its related pathways are Prolactin Signaling and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.Gene Ontology (GO) …Mar 22, 2021 · A gene is the basic physical and functional unit of heredity. Genes are made up of DNA and each chromosome contains many genes. Learn how to identify, name, and classify genes, and how they affect human health and traits. Jan 7, 2024 · The Human Gene Database. GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes. The knowledgebase automatically integrates gene-centric data from ~150 web sources, including genomic, transcriptomic, proteomic, genetic, clinical and functional information. .

Popular Topics